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High KLF4 expression was also closely associated with poor grade, late stage, and histological subtypes of simple and complex carcinoma.
Moreover, the high expression level of KLF4 expression was statistically associated with poor grade, late stage, histological subtypes of simple and complex carcinoma, and shorter 24-month survival.
High nuclear KLF4 expression was associated significantly with a more aggressive phenotype as indicated by poor grade, late stage, histological subtypes of simple and complex carcinoma, and shorter 24-month survival in canine mammary carcinoma.
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No difference was found in the percentage of molecular subtypes between simple and complex/mixed carcinomas (Pearson =hi-square P = 0.47).
We obtain a variety of simple bistable networks that we classify into major subtypes.
One class consists of simple point mutants of existing H types (referred to as subtypes, because of a process known as 'antigenic drift').
In the simplest case, large subtypes of cancers are driven by single gene alterations that are directly targetable, such as the Bcr-abl fusion protein of chronic myelogenous leukemia, and others where mutations in a particular pathway are common, but do not represent the single accelerator of tumor growth, such as EGFR mutations in subsets of lung cancer.
The validation of these biomarkers will require the development of simple standardised methodologies across centres and the creation of databanks including cancer types and subtypes, treatments and parameters.
We test the role of glycoprotein charge on sequence data from the three major subtypes of influenza A in humans, using a simple method of calculating net glycoprotein charge.
Because of simple psychology.
Start of simple.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com