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In summary, the DNPR is a valuable tool for epidemiological research of shock and subtypes of shock, especially cardiogenic shock.
We found fairly high PPVs for shock overall, and for subtypes of shock, which makes these ICD-10 codes usable in studies of risk and prognosis based on data from the DNPR.
For subtypes of shock, cardiogenic shock diagnosis had the highest PPV, whereas more patients diagnosed with hypovolemic and septic shock did not fulfill the diagnostic criteria for these two types of shock.
ICD-10 codes for subtypes of shock and simultaneously registered use of inotropes/vasopressors provided PPVs of 96.0% (95% CI: 79.6 99.9) for cardiogenic shock, 69.2% (95% CI: 38.6 90.9) for hypovolemic shock, and 82.4% (95% CI: 65.5 93.2) for septic shock.
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Patients who did not fulfill the diagnostic criteria were equally distributed in groups of patients with unconfirmed shock and patients not fulfilling the specific shock subtype criteria.> -wrap-foot> aShock defined as a confirmed overall shock or subtype of shock by medical chart review.
The subtype of vasodilatory shock (vasogenic in the original article) accounts for the dominant phenotype seen in human septic shock and endotoxemia [9, 32 35].
One of the genes deleted in this region is a subtype of heat-shock protein 90, HSP90AB6.
By univariate analysis, several factors were associated with a lower probability of survival, including older age, AML M1 subtype, higher baseline SOFA score, presence of shock, vasoactive therapy and mechanical ventilation.
In our cohort, we found that older age, AML M1 subtype, higher organ failure score, the presence of shock, vasopressors therapy, and mechanical ventilation were all associated with lower survival.
The increased understanding of circulatory pathophysiology allowed the differentiation and description of shock by Blalock into the different subtypes recognisable today [31].
When dividing the cases into the subtypes of sepsis, severe sepsis and septic shock, our results revealed a significant difference in the genotype and allele frequencies of the rs653765 SNP between the sepsis and severe sepsis subtypes (P = 0.0014) or between the severe sepsis and septic shock subtypes (P = 0.0037) (Table 4).
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