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As a counterbalance, another recently published retrospective study showed that CIN does exist after intra-venous CM administration, but only in subtypes of patients [14].
Similarly, by applying latent class analysis in a sample of 106 remitted adults with bipolar disorder, one study identified two subtypes of patients presenting "good" and "poor" functional outcomes (Reinares et al. 2013).
Kaplan-Meier Survival analysis and log-rank test were performed with these four independent subtypes of patients (Fig. 5C), and differences among them were visually apparent.
However, this route appears to be only present in specific subtypes of patients (145, 148).
Attempts have been made to classify patients into subgroups to better understand which subtypes of patients would benefit from what particular treatment [ 11- 13].
Relating clinical and molecular differences may allow us to define more specific subtypes of patients that respond differently to therapeutic interventions.
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Along the way, the analysis identified discrepancies between our current classification of cell lines and patient tumors, suggesting two major subtypes of patient clusters in breast cancer.
Deficit schizophrenia is a relatively homogeneous subtype of patients which is considered helpful to explore the pathogenesis of schizophrenia.
The stroke subtype of patients were 2 embolic strokes, 3 atherothrombotic infarctions (two were compromised with renal failure and one had insufficient amount of EPA) and one lacunar infarction (who showed high triglyceride level).
This subtype of patients, however, selectively benefit from ErbB2-directed targeted therapies such as Trastuzumab [ 3].
Additional file 1: Tumor marker subtype of patients with ductal carcinoma in situ (DCIS), with and without invasive breast cancer.
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