In order to facilitate high-throughput virtual screening, these scoring functions often treat subtle influences on binding energy like conformational entropy and solvation energy only superficially [ 27, 53], thus sacrificing accuracy for the sake of greater speed.
We cannot exclude that a detailed behavioural assessment could have revealed subtle differences between treated and non-treated mice.
So we can think of the Serpentine Pavilion as an architecture that may look definite and "structural", but is actually a subtle design that treats space and light as visions that constantly shift as you approach the building, or move through it.
Though attacked by contemporaries for exposing Scott's faults, Lockhart's Life is now regarded as an idealized portrait, depicting Scott's success in brilliant colour, indicating his foibles with subtle wit, and treating the follies of the Ballantynes, Scott's first publishers, with partisan disregard for truth.
Words that singers usually take as opportunities for elaboration were sung unadorned, and others usually left alone were treated to subtle decoration.
In conclusion, our results show that the aged human donor lenses can regain the colour of younger lenses by being treated with subtle low-energy infrared femtosecond laser pulses that evoke two-photon events in a target volume inside the intact lens nucleus.
Of course, we cannot exclude more subtle differences between the treated and untreated patients in the different perfusion CT-defined groups, nor between the perfusion CT selected versus non-contrast CT selected rtPA groups, that may have influenced outcomes.
His victory speech that night was emblematic of the subtle way that he would treat race: You know, they said this day would never come.
It's a serious subject and treated with many subtle nods to class and cultural clashes.
On a bed of basmati rice, almost transparent fillets of excellent monkfish were treated to a subtle curry sauce.
