The reverse phenomenon of subtle and pre-symptomatic motor abnormalities in FTLD has also been investigated, although less extensively.
1 19 20 However, communication difficulties are often symptomatic of subtle but pervasive intergroup dynamics problems.
We therefore suggest that self-to-self assessments that reflect a cognitive decline from an individual-adjusted baseline may be required to detect early (and yet subtle) memory deficits in pre-symptomatic human AD.
These health impacts range from subtle, subclinical changes in function to symptomatic, life-threatening intoxication.
Similarly, because females typically have more soft-tissue laxity than males, they may become symptomatic or have impingement with more subtle deformities than males.
Sole reliance on symptomatic outcome measures may not detect these more subtle changes in well-being, functioning and QoL.
As shown in Fig. 11, the differences in the velocities and periods in the control limbs and the asymptomatic and symptomatic limbs of the subjects with lymphedema were subtle or non-significant due to the high variability in the measurements.
These kinds of subtle shifts in the cultural landscape are, in Melanie Challenger's estimation, symptomatic of a growing and dangerous disassociation from nature that is directly responsible for the post-industrial rash of extinctions that have afflicted our planet.
The degree to which a particular cognitive or functional measure is responsive to changes in disease status is extremely important, particularly in pre-symptomatic and aMCI populations where cognitive decline is slower and more subtle [ 33].
Subtle metabolic changes in cartilage and other joint structures slowly progress through a long clinically asymptomatic latency period to a symptomatic phase with joint pain and dysfunction.
