The core clinical features of UCB encephalopathy may range from mild mental retardation and subtle cognitive disturbances to deafness and severe cerebral palsy, seizure or death from kernicterus [2], [5].
However, taken together evidence exist to conclude that blood CTG repeat expansion size correlates with cognition, especially when considering the entire DM1 spectrum, which ranges from mental retardation (congenital DM1) to subtle memory deficits (minimal DM1) [ 14, 9].
A wide array of fetal disorders can be induced by alcohol consumption during pregnancy, from subtle changes in intelligence to severe mental retardation and physical disability [ 1].
The only previously known human LARGE mutations (p.E509K and p.C667fs) were identified in a patient with CMD, subtle structural brain abnormalities and severe mental retardation (MDC1D).
Currently, it is difficult to relate the subtle TMS changes with the clinical picture of psychomotor retardation, persistent symptoms, and prominent disability seen in patients with VD.
Sensorineural hearing loss, seizures, motor problems, hydrocephalus and mental retardation [ 4, 7- 10], as well as more subtle outcomes like cognitive, academic and behavioral problems are observed in post-meningitis children [ 5, 11].
Compared with patients with other seizure types, those with subtle and generalized tonic seizures had a significantly higher prevalence of epilepsy (P =.04 and P =.01 respectively); mental retardation (P =.02; P =.007), and cerebral palsy (P =.03; P =.002).
criterion for mental retardation".
Moderate-severe retardation.
