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The microscopic epithelial precancers grow by a subtle replacement of the normal mucosa, without producing a mass, despite many replicative cycles of growth.
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She has a page filled with party snaps on Style.com, and her hipness quotient was impressive enough to have drawn the attention of Gérard Darel, the French fashion house, which featured her in a series of print campaigns as the replacement for subtle beauties like the Gallic singer and actress Charlotte Gainsbourg.
Possibly uremia is the most potent factor which triggers immune activation, and further changes induced by the different types of renal replacement therapy are too subtle to be apparent.
Besides the direct effect of land substitution, which Searchinger and colleagues determined using a well-established worldwide economic model, there were some more subtle effects that exacerbated the need for replacement farmland.
Mr. McVey called the replacement of Mr. Thain with Mr. Blankfein a "subtle shift" rather than a loss that would handicap the firm.
Finally, Patient 1 – who harbours a severe loss-of-function missense mutation (S74I) – had long-standing evidence of subtle disturbances in renin-aldosterone and was eventually commenced on fludrocortisone replacement at 4 years of age (Fig. 1) as it was felt she had a subtle form of adrenal hypoplasia.
The wizardry begins at 0 54; it is subtle stuff compared to what was to come in later years, but the strategic replacement of various kick and snare hits nonetheless adds elements of rhythmic surprise; in places the beat takes centre stage.
For patients with normal or elevated BMI, caloric replacement is helpful to achieve weight loss, greater metabolic control, and avoidance of subtle deficits of vitamins or other nutrients that can accompany simple calorie restriction [ 69].
More subtle molecular clock issues arise from the fact that mutations can result in variable amino acid replacement rates in proteins, especially among primates.
We examined whether these subtle deformities of the hip are associated with the development of radiographic OA and total hip replacement (THR) in women.
At woodland sites, responses to stand replacement prescribed fire, clear-cutting, and tree mastication treatments applied to 10 20-ha 10 20-hare subtle: 1) no changes were observed in community structure; 2) Melissa blues (plotsjus melissa) and sulfurs (Colias spp).
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