While the micromass culture system is able to recapitulate expression of the major markers of chondrocyte gene expression, subtle, physiologically relevant differences could be overlooked in this model.
These QTL×environment and QTL×QTL interactions suggest that subtle ecologically relevant changes in light, temperature, and relative humidity are differentially felt by alleles controlling flowering time and may be responsible for adaptation to regional environments.
This might reveal subtle but relevant differences in NOS views between students as well as changes in the views of individual students over time.
Figure 1 illustrates an exemplar trial sequence and target gratings, and Fig. 2 illustrates the subtle response-relevant difference between high and low spatial frequencies of gratings.
Given the number of probes on the array, a more detailed gene structure classification might increase the potential to observe subtle biologically-relevant trends in DNAm.
Here we test how cell-to-cell variability in time-to-death (Td) is affected by the inherent stochastic variability in apoptotic signaling as compared with subtle physiologically-relevant variations in protein concentrations.
Often, however, the poor dynamic range of such reporters prevents detection of subtle but physiologically relevant signals.
Cannily, they have not focused too much on their chances of winning the cup but have rather stressed their ability to defeat Bayern - a subtle, but psychologically relevant difference.
These studies aim to differentiate subtle changes in relevant features from other biological and technical variation.
