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Subtle reduction in the tumor suppressor PTEN has been linked to various malignancies.
By contrast, normotensive anemia (1 1 HES/blood fluid exchange) preserved global organ perfusion but was unable to prevent a subtle reduction in brain tissue PtO2.
Histological analyses of the femur and tibia in the mutants show subtle reduction of chondrocyte numbers in epiphyseal-plate columns, reduction of matrix, and near absence of osteoid below the differentiated chondrocytes.
Characterization and uniqueness of optimizers of Riesz-type functionals were established in [3], our new approach also allows us to weaken (Ψ3) of [3]; thanks to a subtle reduction of the Riesz-type functionals to the Hardy-Littlewood ones (Theorem 2).
For instance, a person's asthma will be deeper than his or her skin rash, a person's fear of death will be deeper than his or her irritability, and a person's loss of self esteem will be deeper than a subtle reduction in memory.
A subtle reduction in the recovery kinetics of SR45/U1-70K complex was observed with staurosporine (Figure 7).
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Subtle reductions in IQ are an attribute of BD (Cardenas et al. 2016) and do not appear by chance due to our study design.
An experimental model of intraperitoneal insufflation with CO2 found only subtle reductions in microcirculatory flow in the small bowel mucosa [22], which could be completely explained by decreases in cardiac output.
Furthermore, our short-term (three weeks) sub-colony experiment does not rule out longer-term effects of changes due to ant-fungus-bacterium combinations, such as more subtle reductions in biomass accumulation.
It should also be considered that whilst half maximal effective and inhibitory (EC50 and IC50) concentrations are the conventional means of reporting experimental data, far more subtle reductions in function could have clinically relevant consequences.
The rhythms of control flies were relatively constant across five weeks, although some gradual and subtle reductions in relative peak size and number per day were observed (Figure 5A).
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