This observation suggests the subtle structural plasticity of these chiral peptides with the identical sequences.
While the genetic ablation of ERK2 in mice results in embryonic lethality, loss of ERK1 only causes deficits in tymocyte maturation and subtle alterations in synaptic plasticity and behaviour [12], [13].
TauP301S transgenic mice develop Tau hyperphosphorylation, robust Tau-pathology, astro- and microgliosis, hippocampal atrophy, subtle defects in synaptic plasticity and motoric deficits, followed by the development of a progressive neurodegenerative phenotype characterized by initial clasping, hindlimb paralysis, development of hunchback, followed by premature death [ 73].
These results highlight the importance of population level analyses to i) illuminate the subtle interplay between selection, plasticity and gene flow in the evolution of adaptive traits and ii) demonstrate that evolutionary processes may act simultaneously and that their relative influence may vary across different environments.
Although the overall structural integrity is well maintained and they exhibit similar mechanism of activation, subtle conformational changes and structural plasticity especially in the flexible loop regions and domain interfaces lead to differences in their active site conformation and hence in their specificity and functions.
The task is sensitive to lesions of the hippocampus [1 3] and to subtle manipulations of hippocampal synaptic plasticity [4].
In other words, the analyses of natural and engineered dicentric chromosomes indicate that epigenetic plasticity, but also subtle genetic features of centromere-competent DNA sequences, plays an important role in defining centromere identity.
The alteration of phenotypic plasticity can be subtler.
Although the modeled structural changes are subtle, our results on predicting sequence plasticity suggest that backrub sampling may capture a sizable fraction of localized conformational changes that occur in proteins.
However, phenotypic plasticity can also encompass subtle trait variation, such as the phenotypic response of bone to biomechanical function [ 9].
