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Virtual buildings didn't age like physical ones, but they aged in subtle pathways of arcane decline, in much the way that their owners did.
Motoyama was especially interested in the physiology of the meridians, or subtle pathways and vessels, and the qi or subtle energy hypothesized to flow through or get stored in them.
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Altogether, our results suggest that constitutional CNVs may modulate subtle pathway changes through specific pathway enzymes, which may become fixed in some populations.
BRAF binds to and activates CRAF in a RAS-dependent manner that appears to require CRAF transphosphorylation by BRAF (Garnett et al., 2005; Rushworth et al., 2006; Weber et al., 2001), providing subtle pathway regulation that is not fully understood.
It has been reported that caspase activation may contribute to subtle signalling pathways, some of which may enhance cell survival and proliferation [ 34].
Our results suggest that CNVs may modulate subtle changes in pathways at specific nodes, which may become fixed in certain populations.
As oxidative damage does not accumulate markedly in mutator mice, the mtDNA mutations may activate mitochondrial ROS production as part of subtle redox signaling pathways that contribute to accelerated aging.
GSEA can be used to identify subtle but consistent pathway changes in microarray data when analysis at the individual transcript level cannot detect statistically significant variation.
The detail of growth factor receptor kinase ER interplay remains controversial in such cells, although it seems likely that there are subtle differences in pathway detail versus tamoxifen resistant states.
The effects of activation of the mating pathway and osmotic stress pathway were subtle, with the dominant specie in either case still consisting of monomeric Ste50 interacting with Ste11.
The predicted functional linkages augment the search space responsible for the biosynthesis of the crucial components of cell wall apart from providing a rationale for the analyzing of network hubs and understanding the subtle relationships between various pathways.
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