The p.R279C had a high functionality score as predicted by pathogenicity predictors (Table 1), whereas detailed in silico prediction analysis showed only a subtle order-enhancing effect (Fig. 4) consistent with the fact that this is a common variant with a modest effect size (OR = 0.64).
The makeup on skin must be soft and colors must be subtle, in order to enhance your natural beauty instead of creating a whole new, fake face.
Subtle pecking-order arrangements emerge that can dampen enthusiasm or exaggerate one individual's organizing skills.
But in the buildup to Sunday's showdown, one or two journalists suggested a subtle re-ordering of that phrase.
Inside the ballroom, in the not-so-subtle pecking order of the Globes, ringside seats were reserved for movie royalty, while television powers sat mostly one flight up.
To combat this myth of the "neural zombie" inside our heads, choosing how we act, Noë argues that despite how it looks when a musician or athlete is "in the zone," or in the seemingly effortless "give and take" of our normal conversations, we are indeed still thinking; our attention has simply moved from self-conscious grappling with basics to subtler, higher-order patterns and decisions.
A subtle and fantastic order may appear in the digits of pi way out there somewhere; no one knows.
As she paints images for us of Daniel's brief life under the waves as a seal, she shows writing of the highest order: subtle, powerful, poetic.
Examples include "not visible" for "invisible", "not healthy" for "unhealthy" – as well as tinkering with word order, subtle variations in punctuation, and so on.
In this context, surveillance is no longer the sole preserve of the veiled watcher, but rather is increasingly found in the subtle grid of order created by our access cards, documentation, virtual identities, and even household appliances.
