If nothing else, it keeps the giggle quotient up, and offsets the queasier moments, such as the not-so-subtle latency of Burgundy's sports-jock pal Champ, or a distinctly misjudged jive-talk scene at an African-American family dinner.
While this site shows onset responses to both SV and PB, there is a subtle difference in latency seen in the HGB responses, with the earlier HGB response to SV preserved but a later response slightly attenuated compared to the PB condition.
Alternatively there may be important but subtle effects on viral reactivation and latency as evidenced by experiments in the susceptible BALB/c strain where single responses have been deleted through viral mutation [47].
Although it is thought that efficient establishment of alphaherpesvirus latency is based on a subtle interplay between virus, neurons and the immune system, it is not clear which immune components are of major importance for the establishment of latency.
In this mouse model, the tumor latency is long enough that subtle oncogenic perturbations would be detectable, yet short enough to be experimentally tractable [23].
The results may suggest that PM may result in a delayed processing perhaps due to subtle hearing loss resulting in longer P1 latencies in children with exposure to PM [ 36].
Similarly, tau pathology may be associated with clinical oculomotor features of decreased saccade velocity and gain (as in PSP), increased saccade latency (as in CBS) or more subtle deficits in anti-saccade control and smooth pursuit (as in PA).
Although there is direct and indirect evidence to support the general concept that alphaherpesvirus latency and reactivation is based on a subtle interplay between virus, neurons and the immune system, many questions remain about the immune components that are involved in the establishment of latency [4].
These myriad effects imparted by EBV latency programs likely perturb many cellular functions in subtle ways that can increase spontaneous transformation or otherwise potentiate cells for transformation.
Moreover, insisting on human studies would result in failure to identify some human health risks because the diseases are rare, or the induction and latency periods are long, or the effects are subtle (Cranor 2011).
Interestingly, subtle physiological influences, including stress hormones, can trigger EBV reactivation from latency causing temporary enhanced viral gene expression and triggering aberrant immune responses (Glaser et al., 2005).
