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PES might look a lot nicer in 2017 than it did in 2016, but the frills are still subtle in comparison to the opposition.
First, like deletion of Mvb12p which results in a partial defect in MVB sorting that is relatively subtle in comparison to loss of other ESCRT-I subunits [17] [20], depletion of MVB-12 delays but does not block receptor downregulation in C. elegans, unlike the much more severe phenotype seen following depletion of other ESCRT-I subunits.
Although some SMIPs (005, 006, 016) caused a ~twofold increase in the percentage of NKX3.1 positive cells, the effect was subtle in comparison to proteasome inhibitors (~fivefold; Figure 4c) and could not be confirmed by immunoblotting (data not shown).
Thus, although adaptive changes in TLR genes may be subtle in comparison to other components of the immune system (Piertney and Oliver 2006; Downing et al. 2010; Quintana-Murci and Clark 2013), these genes should be incorporated into research aiming to understand associations between genetic variation and susceptibility to pathogens in natural populations (Tschirren et al. 2013).
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Thus any differences in V1 BOLD signals might be subtle, particularly in comparison to brain regions selectively engaged for object recognition.
However, we noted that WT-like KO EBs exhibited similar expression patterns of these genes with subtle differences in comparison to WT EBs.
It is interesting that inhibition of the fourth yeast subunit, Mvb12p, also exhibits a relatively subtle defect in comparison to loss of the other ESCRT-I subunits [17] [20], exhibiting only a partial defect in MVB sorting.
An aggregate measure of the thickness of the AD cortical signature regions in these asymptomatic older individuals revealed subtle thinning in comparison to the large group (N = 115) of OC individuals from Sample no. 1 whose amyloid status is unknown.
The milder phenotype of dominant mutations reflects the subtle KATP channel defect in comparison with recessive mutations, which lead to defects in channel biogenesis, trafficking and assembly.
Intriguingly, in comparison to this, subtle differences were observed in the mycobacterial phylogeny based on the GSIβ protein sequence, although the phylogeny based on the GSII sequence reflected the proposed mycobacterial speciation more closely.
On the male parasite side, the effects of sexual pairing on male worms are very subtle and therefore have received little attention in comparison to female worms.
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