As the changes in physiological conditions are relatively subtle from one tissue to another and the concentrations of specific enzymes are often quite low, a release strategy involving the amplification of a biological signal is particularly attractive.
It is "the separation of the gross from the subtle and the subtle from the gross... to make the spiritual lighter by its subtlety" (Hieronymus Brunschwig, 15th century doctor and distiller).
There are ubiquitous design elements, some striking, others subtle — from bamboo floors and playful light fixtures to curvilinear walls with tiny red glass beads evocative of flying-fish roe.
The colour palette was narrow and subtle – from heather to chestnut brown to the dark green of a lawn in shade – the shades of nature in autumn drizzle, with nothing so vulgar as a pop of colour to be seen.
The second problem is that, as an insider, Denholm has already supposedly been providing independent oversight during some of the most unsettling periods in Tesla's history; precisely those periods when that oversight seemed – how to put this? – intensely subtle from an outside perspective.
Some of the tweaks were subtle, from pinning Juan Mata primarily to the right flank, to barking orders at Eden Hazard to track back and assist Ashley Cole, and even to the players undertaking warm-downs on the pitch after the game.
