Interestingly, Parkin-deficient mice treated for 3 6 months with repeated, low doses of systemic LPS developed subtle fine-motor deficits and DA neuron loss that were more pronounced than in wildtype controls [122], indicating that enhanced neuronal vulnerability to inflammation may play a role in recessive Parkinsonism.
This would be consistent with the idea that miRNAs function in a subtle fine-tuning of the immune response [ 1].
The overall response indicates that the developing zebrafish embryo responds to nutrient depletion by subtle fine-tuning of its metabolic pathways.
In the context of expertise, differences in the integrity of white matter microstructure may reflect a subtle fine-tuning of white matter connectivity to optimize performance on a specific task.
These overlapping binding specificities allow regulatory plasticity, which underlies tissue-specific splicing patterns, subtle fine-tuning of splice variant levels, and regulatory relationships between splicing regulators and upstream signaling pathways.
Sometimes the way airlines price tickets is so subtle, the fine points will be missed by computers, he said.
And now I know why they go on about the maple stuff: it's subtle and fine, less like syrup and more like liquid caramel with a hint of citrus.
The technique also is less subtle and fine in the London work.
Taken together, these in vitro studies have revealed a subtle and fine-tuned mode of regulation of B-Raf activity.
This suggests that the more subtle or fine-tuned regulation by miRNAs of gene expression may not be involved in sexually dimorphic expression changes during this time.
Letting go of his beloved in the way he does, freeing her to follow her heart's deepest affections, does not mean to deny the feelings he has toward her, but on the contrary, to raise them to their subtlest and finest station.
