Whereas the core symptoms of hyperactivity, impulsivity and inattention, are well characterised in children, these symptoms may have different and more subtle expressions in adult life.
The incidence of CS in the general population is difficult to ascertain due to the variable and often subtle expression resulting in difficulty in diagnosing proband patients.
The most common changes are associated with metabolism, but more subtle expression changes in genes involved in genomic homeostasis are also evident.
GSEA has proven to be useful for capturing subtle expression changes in complex gene signatures based on predefined gene sets or pathways [22].
The simple syntactical nature of logical negation belies the profoundly complex and subtle expression of negation in natural language, as expressed in linguistically distinct categories and parts of speech (adverbs, verbs, copulas, quantifiers, affixes).
In consequence, subtle expression changes of weakly expressed genes potentially get lost in WAD-lists.
This indicates that both Myc copies, present on medaka chromosomes 17 and 20, are expressed during development in a comparable pattern, but differ in subtle expression domains.
There is low sensitivity and a limited capacity to quantify subtle TSPO expression in vivo.
Moreover, although CK20 shows a subtler expression prolife (low in IH‐CC, high in EH‐CC, and variable expression in PDAC), it demonstrates a high biological and methodical variability, rendering it an unreliable marker for pancreatobiliary cancers.
Instead, we can postulate that the degree of aggressiveness of the disease might trigger subtle changes in expression in the biological functions represented by these modules.
