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These complexities may be further enhanced for CD8 18 which is known to have several distinct roles in T cell activation 2– 4. Here, we find that these intricacies are open to subtle exploitation by showing that even a small increase in the interaction between human pMHCI and CD8 can result in a substantial improvement in the recognition of MHCI-restricted antigen by cognate CTL.
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We identify three fundamental features responsible for the observed exponential distribution, which arise from a subtle interplay between exploitation and exploration in research-interest evolution5,22.
"They may have been subject to a subtle form of exploitation that results from some parents' inability or unwillingness to parent them.
There is room for interpretation, and many of the dual relationships social workers encounter are much more subtle than the egregious exploitation of a sexual relationship.
Therefore, to design highly selective CAIs requires the exploitation of subtle active site differences; predominantly residues found in the hydrophilic and hydrophobic pockets [ 22].
These methods require a matrix that is non-denaturing allowing for the exploitation of subtle differences in mobility due to changes in secondary structure created by DNA sequence variability.
Audiences came in droves for the visceral thrills of rampant dinosaurs and the ensuing mayhem, but beneath the flash, the film offered a not-so-subtle commentary about the exploitation of animals, and very much nature itself, for commercial gain.
In the 21st century, the systems of exploitation are more subtle, the abuse neither so conspicuous nor dramatic, but Smith sees parallels in what is happening to those brought to Australia now.
Today, the PRC is engaged in a subtle dual strategy of network penetration and data exploitation.
Our results overall highlight the potential for large, harvest-induced population-level consequences to emerge from rather subtle phenotypic changes in response to positively size-selective exploitation that might easily go unnoticed when monitoring natural populations.
Next to a real commercial it would have been subtle; next to the day's news it was an exploitation bending over backward not to look like one.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com