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Thus in our formulation, we focus only on the first two effects, leaving the more subtle effects for future consideration.
For example, in a similar study with hTRβ, the nature of the flanking sequence between the two half-sites (that does not make any direct contact with the P-box) showed itself influence on the lability of 1st, 2nd and 3rd P-box positions (with the more dramatic effects for the first one and only subtle effects for the 3rd position) at the recognition of AGGNCA half-sites [ 30].
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Analyses of genetic polymorphism data require immense care and power to distinguish the generally subtle effects of, for example, recombination and demographics.
This is a subtle effect for any single gene, affecting on average only ~1 2 amino acids per peptide, and can only be confidently established by means of the large number of genes available for analysis.
Although dose reductions of only a few single genes are directly deleterious (haploinsufficient), the subtle effects of dose reduction for most genes are cumulative and may eventually lead to the collapse of the regulatory network.
Thus, evaluating this set of mutants provides a potentially sensitive analysis for subtle effects of loss of exocyst function, i.e. small differences in the mutants can be considered more credible when the magnitude of those differences consistently correlate with the severity of the root growth defect across all mutants evaluated.
In a quite unrelated effort, his group prepared spiro[4.4]nonatetraene, one of the first test cases for the subtle effects of spiroconjugation and an example of organic synthesis in the exploration of a basic issue of bonding theory.
Professor Spector is looking for the subtle effects of epigenetics - the chemical instruction manual that overwrites the genetic code, dictating when genes are switched on or switched off.
A much finer-scale manipulation that more accurately mimics natural male coloration is now needed to test for more subtle effects of retinal carotenoids on visually mediated mate selection.
Whether this method is also useful for analyzing more subtle effects of neuroprotective treatment (partial protection) remains to be established, by studying mice with small dopaminergic lesions.
One explanation for the comparatively subtle effects of the Exo1-4S∷A and Exo1-4S∷E mightions might be that other serine (threonine or tyrosine) residues were phosphorylated when the primary kinase targets had been mutated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com