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It thereby showed the necessity to use objects treated as reference standards across the various sites to ensure that no subtle drift was present, or that a scheduled software upgrade on a machine did not change the results dramatically [6].
These results also indicate that TF specificity is not generally subject to subtle drift, but tends to either stay very similar or evolve to a distinctly different state.
To characterize the role of divergence and subtle drift in TF DNA binding specificity in animal diversity, we used HT-SELEX to determine TF binding specificities in Drosophila melanogaster.
DOI: http://dx.doi.org/10.7554/eLife.04837.028 To detect more subtle drift in TF specificity, we analyzed conservation of dinucleotide preferences resulting from structure-based TF-DNA recognition (Rohs et al., 2010; Jolma et al., 2013).
Our results suggest that morphological divergence is not driven by subtle drift in specificity of TFs, but primarily caused by cis-regulatory changes (Carroll, 2000; Levine and Tjian, 2003), with some contribution from relatively large shifts in binding specificities of specific TFs.
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I am sitting there, rereading Michiko Kakutani's review ("misconceived and offensive"), wincing, laughing, biting my nails, marvelling at the power of the critic and also at the baseness of the critical pursuit, when I hear a voice, elegant, subtle, drifting from my Sony boombox (vintage 1994).
Subtle colors often drift into view, like objects in the fog, unfocused memories or intuitions on their way to becoming heartfelt convictions.
Their performance of Adams's Chamber Symphony has real rhythmic snap, pungency in the instrumental textures, and just the right edge of aggression; the last of Ives's Three Places in New England, The Housatonic at Stockbridge, becomes a wonderfully subtle study in drifting textures with the ghostly presence of a hymn tune threading through it.
These observations also raise the possibility of more subtle and continuous drifting of centromeres relative to their underlying chromosomal positions.
Unveiling specific interactions between MNPs and the molecular structure of ORMOSIL, this work investigates subtle structural aspects through DRIFT spectroscopy.
The subtle mutations accumulated through antigenic drift of these subtypes give rise to different strains of each subtype.
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