That suggests that people who are recessive disease carriers could have more subtle disorders.
More subtle disorders of intestinal motility may also be rooted in environmental disruption of ENS development.
Because these tools do not detect subtle disorders in visuomotor, language, memory, or executive functions, specific investigations will be conducted for these functions.
Around one third of patients develop clinical symptoms without histological changes [ 17] and endoscopic and radiographic identification and quantification of subtle disorders remains a problem.
18 The rationale for ovarian stimulation in women with documented ovulation has been to correct subtle disorders of ovulation not identified by conventional tests and to increase the number of oocytes per cycle.
However, environmental factors are also thought to play a role in the pathogenesis of the disease, including exposure to infections, autoimmune responses, stress during gestation or childhood, and subtle disorders of brain development and maturation which do not become apparent until late adolescence and early adulthood (Fig. 1) (Lewis & Lieberman 2000; Lieberman et al. 2001).
The signs of a contemporary child's poor wellbeing were often presented as subtle emotional disorders or displayed in the child's behaviour.
The notion of trait phenotype is usually applied to persistent expressive or behavioral features (e.g., persistent subtle formal thought disorder or inadequate affective modulation).
These results show that at least for the case of relatively short peptides, the interplay between thermodynamic stability and the apparent structural stability can be rather subtle, with even disordered regions contributing significantly to the stability of the folded state.
The common variant p.R279C resides within a PXXP motif, a functional motif in several proteins that confers binding to a range of domains, including SH2 and SH3 (22); analysis of p.R279C showed a subtle tendency of disorder-to-order transition.
