Neuropathological analysis showed diffuse astrocytic gliosis and activated microglia in the white matter, rare prion deposition and subtle subcortical microvacuolization, and patchy foci of demyelination with no evident white matter axonal degeneration.
We conclude that the dynamic process of evaporite deposition led to subtle stratigraphic heterogeneities and changes in bed thicknesses, but largely continuous lateral bedding at an interwell-scale.
In particular, normal individuals with PiB deposition may show subtle signs of cognitive change if amyloid-beta deposition marks an early stage of pathophysiological change.
If either subtle cognitive impairment or amyloid deposition in brain consistently predicts AD dementia, it should be considered an early stage of AD.
One might deposit materials using thermal deposition.
Subtle change of the nanometer-scale structures with the deposition angle was clearly discriminated from the viewpoint of transient catalytic activity.
This indicates that the independent deposition approximation is not perfect and that subtle interplays between the precursors exist.
On the one hand, production, transportation, deposition, and preservation of dust respond sensitively to subtle changes in climatic conditions (Ding et al. 1998, 2002; Rea et al. 1998; Guo et al. 2002; Maher et al. 2010; Roberts et al. 2011).
Our data suggest that the Aβ deposition commonly detected in normal older individuals is associated with subtle posterior cingulate and parietal neurodegeneration that occurs prior to, and may be a harbinger of, clinically significant impairment.
