Sentence examples for subtle degeneration from inspiring English sources

However, current imaging markers of neurodegeneration, such as quantitative MRI of cortical thickness or hippocampal volume, also lack the sensitivity and specificity to detect subtle degeneration within different neocortical or hippocampal layers in the early stages of AD.

These mice produce soluble and insoluble Aβ aggregates, Aβ plaques and they show neuron loss in CA1, loss of asymmetric synapses in the frontocentral neocortex [ 22, 23] as well as more subtle degeneration of a subtype of layer III commissural neurons in the frontocentral neocortex, i.e. the degeneration of commissural neurons with a highly ramified dendritic tree.

This subtle axonal degeneration may be visualized by magnetic resonance spectroscopy (1H-MRS) as reduction of N-acetyl-aspartate (NAA) levels [9] [14].

If so, a predication of global and more subtle progressive axonal degeneration would be very difficult.

Nonetheless, it is not easy to evaluate correctly such often subtle LV myocardial degeneration.

The axons in the ROCK2-shRNA group also slowly developed subtle signs of degeneration like axonal swellings, but did not fragment within the 6 h time period in contrast to the control axons.

Whereas articular cartilage has been the subject of intense research in the context of joint degeneration, subtle changes in meniscal composition may be more closely associated with the true 'onset' of knee osteoarthritis [ 52].

Tau accumulation, phosphorylation and axonopathy can be subtle and precede neuronal degeneration, tangle formation and cognitive or behavioural deficits [36], [37].

Even though we cannot rule out the possibility that subtle axonal changes and degeneration may still occur in MS GM, such alterations are unlikely to result in OPC loss and the complete lack of remyelination observed in chronic SCD.

It is important to remember, however, that both FUS−/− mouse models were reported 9 years before the first reports of FUS in ALS (Kwiatkowski et al., 2009; Vance et al., 2009); while paralysis of FUS−/− mice would be obvious, it is unlikely that these FUS−/− mice were monitored for more subtle signs of motor neuron degeneration.

It covers events such as the Three Mile Island nuclear disaster, along with subtler signals of the leisurely degeneration of American life.