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7 However, the MMSE is unable to detect subtle declines in cognitive aging.
Longitudinal studies that have used "normal" cognitive status as an inclusion criterion have found that even "normal" aging may contribute to subtle declines in cognitive functioning.
However, others have argued that changes in mammography use are more likely to be responsible, because subtle declines in breast cancer incidence began in 1999, predating publication of the Women's Health Initiative trial results, and because of the uncertain biological plausibility of an instantaneous change in risk after HT cessation [ 5].
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The Daqing Oilfield is one of the China's largest oilfields since the 1950s and has reached a steady state of production since the 1970s, with recent subtle decline in production.
RT-PCR analysis indicated that homozygous enarev showed a significant reduction in ena expression, whereas a single copy of P[UAS]117 (as in enarev/+) resulted in a subtle decline in ena levels, consistent with its lack of effect on the behavioral paradigm (Figs. 4G and 2A B).
Lithium causes a subtle decline in glomerular filtration rate; renal function needs to be monitored in patients on lithium treatment.
Several studies have shown that long-term lithium use is associated with a subtle decline in estimated glomerular filtration rate.
In E. grandis, a significant decline in rooting ability was observed as the distance of the cutting source from the ground increased, although only a subtle decline in miR156 expression was observed in the same plant samples.
These factors might contribute to the larger λdiff and λlag compared to the fallers but might also indirectly reflect subtle decline in balance and mobility in the fallers group.
A subtle decline in OXPHOS is associated with skeletal muscle atrophy, type 2 diabetes, neurodegeneration, and the aging process itself (Vafai and Mootha, 2012), though the molecular basis and biochemical consequences are currently not known.
Nonetheless, it is apparent that a change in practice for the routine long term follow-up of Fontan patients is necessary in order to detect progressive subtle decline in status and to have a favourable impact on the functional status of these unique survivors (table 3).
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