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First, coagulopathy in sepsis is a dynamic process, evolving from subtle activation of coagulation to overt DIC.
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In some cases (for example, congenital metabolic diseases), it may be possible to identify a single, robust diagnostic metabolite, but in many cases the perturbations are more subtle, involving the activation of multiple enzymatic pathways.
In humans a subtle method for recording activation of the trigeminal pathway and of brainstem mechanisms, is that of the blink reflex.
We observed that treatment of cells with Triphala caused subtle but statistically significant activation of ATM as evident by phosphorylation at Ser 1981 (Fig 2A).
Slow and subtle movements result from the activation of slow muscle fibers.
The hyperuricemic rats developed subtle renal injury associated with activation of the reninangiotensin system and development of hypertension.
It is also clear that a subgroup of depressed patients may manifest subtle thyroid abnormalities, or an activation of an autoimmune process, however the cause of this phenomenon and its implications are unclear.
The absence of observed specificity for other BH3-only proteins, particularly Bid/tBid and Puma, may suggest that subtle differences exist that govern activation of Bim expression compared with Bid and Puma.
Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that the underlying molecular mechanism of chemoprevention by these agents does not involve increases in TGF-β expression.
Although we cannot rule out more subtle effects on TGF-β activity, such as the activation of latent forms, the data suggest that TGF-βs are not involved in the underlying molecular mechanism of chemoprevention induced by these agents.
The government's actions have been described as Soviet in style and intent but the political thuggery pales compared to the activation of a subtler and more powerful effect known as psychological distance.
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