Sentence examples for substrates with important from inspiring English sources

We chose five different neuronal substrates with important functions in the developing and adult nervous system and studied the cleavage of these in membrane preparations from E17 and 3 month-old rats.

SIRT1 is the most well-characterized member of the sirtuin family and has a wide spectrum of substrates with important functions in aging, metabolism, and cancer.

GPx4 (phospholipid hydroperoxide GPx) is a membrane-bound protein that accepts phospholipid hydroperoxides in membranes as substrates with important function in spermatogenesis (Imai et al, 2009).

Elastomeric coatings have been found to substantially increase the ballistic limit of underlying steel substrates, with an important mechanism being the impact-induced transition of the rubber to the glassy state.

The possibility that p300 is a central regulator of skeletal muscle metabolism is quite high, given that isolated studies have identified a number of p300/CBP substrates with known important roles in skeletal muscle.

A disintegrin and metalloprotease 17 (ADAM17) is a sheddase with important substrates including tumor necrosis factor- α (TNF- α) and its receptors, the p75 neurotrophin receptor (p75NTR), and members of the epidermal growth factor family.

Furthermore, we show that NRP1 associates with PDGFR (PDGF receptor) α in HCASMCs, and that NRP1 inhibition reduces PDGF-BB signalling through p130Cas (Cas is Crk-associated substrate), an adaptor protein with important roles in cell migration [ 17], and which we recently showed to be regulated by NRP1 overexpression in the invasion of U87MG glioma cells [ 18].

Glucose and free fatty acids (FFA) are the two most important substrates, with each inhibiting the metabolism of the other, such that the most prevalent substrate dictates cellular metabolism [ 7, 9].

The consequences of the physiological engagement of calpain-1 with its substrates are important because the spectrum of calpain actions strikingly resemble those that accompany aging of the arterial wall.

This suggests that OATP overexpression and subsequent increased sulfated-hormone cellular influx, along with other substrates, is important in cancer progression, and therefore these proteins represent novel therapeutic targets against estrogen-driven carcinomas.

This role for U2AF35 may be particularly important in substrates with weak pyrimidine tracts that are not bound efficiently by U2AF65.