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Several species of the genus proved very useful cell factories for biotechnology purposes since they produce organic acids, extracellular enzymes, nutraceuticals (isoprenoids), and aroma compounds and are capable of fermenting various substrates under extreme cultivation conditions, usually intolerable to bacteria and yeasts [ 1– 4].
Similar(59)
But, the stability of fungi is not good in practical treatment under extreme environmental and substrate conditions, such as higher pH, oxygen limitation, and high lignin concentrations.
However, an a priori distinction between reversible and irreversible reactions may become problematic under extreme conditions, e.g. depletion of substrates or accumulation of intermediates due to inhibition of enzymes, where metabolite concentrations may drastically change thus allowing to reverse reactions that are normally designated to be irreversible.
This enables the computation of reliable flux distributions even under extreme conditions of the network (e.g. enzyme inhibition, depletion of substrates or accumulation of end products) where metabolite concentrations may be drastically altered.
Our currency is under extreme pressure.
It is also under extreme strain.
They have also lived under extreme conditions.
Under extreme circumstances, radical solutions have to be considered.
The experience of constancy may break down under extreme conditions.
Finally, under extreme duress, we make up.
Certainly he is under extreme pressure.
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