Next, we extended the scope of the carboxylic acid substrate to include electron-rich di- or trimethoxy-substituted benzoic acid derivatives 1 b d.
These peptides were designed to resemble Cbz-l-Gln-Gly, known to be a good TGase substrate, and to include a 1,2,4-thiadiazole group.
These peptides were designed to resemble Cbz-l-Gln-Gly, known to be a good TGase substrate, and to include either α,β-unsaturated amide groups or the corresponding epoxide groups.
In the context of the previously evolved GalK Y371H "gatekeeper" mutation, the active site M173L mutation described herein presents a kinase with remarkably broadened substrate range to include 28 diverse natural and unnatural sugars.
To circumvent ester cleavage, we extended our substrate survey to include propargylic chloride 1 a-Cl [Eq. (4); Tf=trifluoromethanesulfonyl].
A single amino acid difference at position 170 of the GES-1, GES-2, and GES-5 enzymes is responsible for the expansion of their substrate profile to include carbapenem antibiotics.
Finally, progress has been made in expanding in the substrates of nitrogenases to include CO and CO2.
The enzyme was shown to hydrolyze the 3′-phosphate from the substrate 3′,5′-pAp, and the substrate profile was shown to include various 3′,5′-bisphosphonucleotides.
We expected neuronal substrates for this distinction to include cortical midline regions related to self-monitoring (Northoff and Bermpohl, 2004).
The advantages of a circuit-capable substrate is the ability to include sensors such as IR or resistive touch arrays, allowing for people to write on or "click" content.
