Sentence examples for substrates that affect from inspiring English sources

Additionally, discussion on the differences existent between substrates that affect half-saturation indices has been carried out; it has been shown that the observed KS for some substrates will reflect transport or biological limitations more than others.

Supraphysiological levels of pyruvate can directly suppress PGC1α (Fig. 4 D ), adding pyruvate to a growing list of metabolic substrates that affect PGC1α when in excess.

In addition to the biologically relevant amines, a larger group of arylalkylamine substrates were analyzed to understand the general structural features of the amino donor substrates that affect AANATA binding and/or catalysis.

G68C mutation might destabilise or inactivate the mutant protein under conditions employed in the complementation assay or might impair the cleavage of certain substrates that affect cell viability (see below).

As PINK1 is a kinase, it is likely that there are key substrate(s) that affect mitochondrial morphology.

The relative function of the two enzyme could be determined by myriad factors including those that act directly on enzyme activity (e.g., transcription, post-translational modification), the expression of auxiliary proteins (co-factors, inhibitors, proteins that present or sequester substrate) or factors that affect the relative proximity of the enzymes to their substrates.

Based on what we found in the structure, we further performed site-directed mutagenesis of the enzyme, tested the substrate specificity and identified residues that affect the substrate binding affinity and the turnover number of the enzyme.

Mutations that affect substrate carboxyl binding (R71N) and transition state stabilization (R63N) also yielded wild-type aspartoacylase protein levels and undetectable aspartoacylase activity.

Hence, all parameters that affect substrate concentrations or enzyme activity will influence ester production [ 13, 19, 23, 24].

When compared the situation with YBCO films grown on single crystal substrates, the most critical issues that affect the suitable defect formation and thus the optimal vortex pinning landscape, have been studied as a function of the growth temperature and the film thickness evolution.

Finally, using high-content screening methods incorporating GFP-fused cargoes, it might be possible to screen substrates of CDK1 115 for those that affect the protein transport process.