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Modeled substrates suggest that the fingers in the vicinity of the incoming nucleotide is closed, a conformation not previously observed for an unliganded polymerase.
Additional experiments on Al − x Mg binary alloy substrates suggest that Mg ions play the most important role in suppressing the transition of γ- to α-alumina.
Results with various nucleosome substrates suggest that RSC/Sth1 remains at a fixed position on the histone octamer and that Sth1 conducts directional DNA translocation from a location about two turns from the nucleosomal dyad, drawing in DNA from one side of the nucleosome and pumping it toward the other.
The enormous average EFs of the nanowire network AAOs SERS substrates suggest that a gigantic electromagnetic enhancement occurs in the dense 'hot junctions' between the nanowires which exist in W-AAO1-Au and W-AAO2-Au.
Current guidelines for nursery container substrates suggest that after irrigation and drainage, substrates should have 10 30 % AS, 45 65 % CC, 25 35 % available water, 25 35 % unavailable water, 50 85 % total porosity (TP), and 0.19 0.70 g/cm−3 bulk density (BD) (Yeager et al. 2007).
Taken together, the strand exchange data generated using more biologically relevant DNA substrates suggest that RecANg is more efficient than RecAEc at catalyzing strand exchange through regions of microheterology, but that RecAEc is more efficient at catalyzing strand exchange through large heterologous inserts.
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PLX4720 treatment resulted in decreased phosphorylation of p70S6K and 4E-BP1, two known mTOR substrates, suggesting alteration of mTORC1 signaling (Supplementary Fig. 2h).
Some of the chemicals that induce the pump serve as its substrates, suggesting that their extrusion is the natural function of the pump.
c-Abl is active in sporadic PD leading to parkin tyrosine phosphorylation and accumulation of parkin substrates suggesting that c-Abl activation could contribute to the degenerative process of PD9,10.
Behavioral responses were greater toward decayed pine substrates (UV-reflective) than sound pine substrates suggesting that decayed pine can be a useful foraging cue.
We find that the top extraction of light is dramatically improved by increasing the index contrast in patterned substrates, suggesting high-index-contrast patterned substrates containing hollow cavities.
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