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Classical high voltage devices fabricated on SOI substrates suffer from a backside coupling effect which could result in premature breakdown.
In addition, all substrates suffer from the significant drawback that they generally lack selectivity.
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However, the arsenate SERS detection at low concentration using Ag/GL substrates may suffer from the interference of the nearest background band at approximately 815 cm-1.
Comparison with an SH2 domain array study reveal limitations in that technique and suggest that SH2 domain arrays on glass substrates may suffer from a high rate of false positive and false negative interactions.
TCO films fabricated on flexible substrate may suffer from cracking after repeated bending.
The flexibility of soft templates allows imprinting over uneven substrates but today they suffer from laterally varying residual layer thickness in-between the imprinted structures, which cannot be removed by conventional processes.
The results show that the lattice distortion is inevitable as the diamond substrate suffers from the mechanically induced effects, which produces an amorphous layer on the surface.
Notably, in all cases, KM values were in the millimolar range and did not suffer from substrate inhibition.
Existing on-chip spiral inductors based on conventional planar integrated-circuit fabrication technology suffer from substrate loss and parasitics, and have relatively large area.
Murine models lacking active GALNS do not successfully recapitulate the human skeletal disorder, as unlike the patients, they do not exhibit skeletal deformities, but do suffer from substrate accumulation in the brain [26], [27], [28].
Although multiple classes of cathepsin-targeted substrate probes have been reported, most suffer from overall fast clearance from sites of protease activation, leading to reduced signal intensity and duration in vivo.
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