Sentence examples for substrates specific to from inspiring English sources

In eukaryotic cells, the exosome complex is present in the cytoplasm, nucleus and especially the nucleolus, although different proteins interact with the exosome complex in these compartments regulating the RNA degradation activity of the complex to substrates specific to these cell compartments.

Genes that originated by duplication might have adapted during silkworm evolution and may cut substrates specific to silkworm.

Activities of collagenases, gelatinases, and MMP13 were determined using fluorescent substrates specific to their activities, and the MMP13 mRNA level was determined using quantitative real-time PCR.

Inhibition of the endogenous 26S proteasome was studied in intact cells and cell extracts using substrates specific to 20S proteasomal enzymes.

The MutT domain of Dcp2p [ 55] and the YjeF-N domain of Dcp3p appear to represent cases where the ancestral active site residues of the pre-existing catalytic domains appear to have been maintained, but they acquired a new set of substrates, specific to the decapping process.

Future structural studies of pol λ and its siblings with substrates specific to each of their unique activities together with studies in cell-based systems and animal models should dramatically enhance our understanding of how these enzymes carry out their specific roles in DNA repair.

These results suggest that a peptide substrate specific to a target intracellular signal is very important for intracellular signals-targeting gene therapy or diagnosis.

DAT is a molecular substrate specific to dopamine neurons and is highly expressed in dopamine neurons of the ventral midbrain, while lesser expression levels are present in the olfactory bulb and hypothalamic areas.

Reactions catalyzed by P450s are highly substrate specific to an extent that even close P450 family members may have widely diverse biochemistries as well as substrate requirements (for review see, Schuler et al. 2006).

Robey et al. [29] demonstrated that pheophorbide a is a fluorescent substrate specific to wild-type and mutant BCRP, and that using a flow cytometric assay with this compound is convenient to determine expression of functional BCRP.

Then substrate specific to HRP enzyme was added (100 μL) to the sample followed by 50 μL stop solution and the intensity of the produced colour was measured with a spectrophotometer at 450 nm.