Without a nitridation step in the LT-21 sample, the thermal cleaning of the sapphire substrates probably may cause more impurity incorporation around the HT-GaN/LT-GaN/sapphire interfacial regions.
This oncogenic effect of p16 depends on the inhibition of CDK4/CDK6 in cancer cells where Rb is inactivated, suggesting the presence of CDK4/6 substrates that may cause cell death when phosphorylated in cells with inactivated Rb 44.
The detachment and fragmentation of coatings during machining will compromise tool performance by the premature exposition of the substrate and may cause wear by fragments of hard and abrasive particles.
Increased content of hexose-6-phosphates demonstrates that a direct inhibition of AG Pase rather than a substrate shortage may cause inhibition of starch synthesis.
Alternatively, the decrease in OXPHOS might reflect an insufficiency of TCA carbon substrates, for the absence of autophagy-supplied substrates may also cause mitochondrial dysfunction.
The lectin activity of human plasma kallikrein may cause substrate specificity, since kininogen, the substrate of plasma kallikrein, is a glycoprotein.
15 Therefore, administration of ATV and drugs primarily metabolized by these isoenzymes and/or substrates of P-gp may cause an increase in plasma concentrations of the concomitant drug, potentially enhancing or prolonging both their therapeutic and adverse effects.
Proteins can be affected either by introducing covalent bindings, interfering through weak, but multiple non-covalent interactions, or the deposition of lipophilic compounds in hydrophobic regions of proteins e.g. within substrate binding pockets, which may cause loss of activity, total inhibition, or degradation.
Being a substrate of the efflux transporter, verapamil may cause competitive inhibition of the transporter function and, therefore, its inhibitory potency depends on the degree of interference with another substrate (in our case rhodamine B) when both bind to the substrate binding site of the protein.
Under the certain conditions, changing the substrate temperature or the pulse laser energy may cause the changes of the growth modes of the CdS nanoneedles.
