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This suggests that the activation of calpain is involved in the sensitization of nociceptive neurons what is partly due to neurofilament breakdown but cleavage of other calpain substrates may also be involved.
Although many of such substrates may also be coated by other means like the sol gel method, there are coating materials (e. g. refractory metals) for which PVD processes are the method of choice.
The differential activities of TRF2 on DNA and nucleosomal substrates may also influence how TRF2 interacts with other proteins such as members of the shelterin complex [8].
Growth with high-energy substrates may also lead to a growth strategy of maximal ATP production.
Poor aqueous solubility of hydrophobic ketone substrates may also be a problem in such reactions [ 13].
However, although this hypothesis is a possibility, the accumulation of LAM substrates may also indicate inhibition of LAM synthesis.
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Aluminium diffusion inwards to the substrate may also be beneficial to the thermal oxidation resistance.
Finally, we note that the doping condition of the substrate may also play a role in the nanooxidation process.
It is possible that glycerol as a co-substrate may also play a protective role under stress conditions caused by high initial concentrations of the substrates and/or product.
We reasoned that if the phosphorylation of a single substrate is responsible for the synthetic lethality of the ste20Δ cla4Δ mutant, then the gene coding for that substrate may also be essential.
However, recent data suggest that ubiquitylation of H2B may not be the sole determinant for these modifications in yeast, and that another Bre1 substrate may also be involved [ 21].
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