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This study demonstrates that the localization of focal adhesion on well-defined micropatterned substrates is critically determined by the topographical variation in the micropatterns.
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Transplantation experiments of typical reef sponges to mangrove roots revealed that reef species deteriorated quickly after transplantation to coastal mangrove roots (Farnsworth and Ellison 1996; Wulff 2004; Pawlik et al. 2007), where the root substrate is critically important in limiting survival of reef species in mangrove systems (Hunting et al. 2013), while mangrove species remain unaffected.
Studies from site-directed mutants revealed that Asp170 is critically involved in substrate hydroxylation.
Metabolism of glucose and of other energetic substrates, such as pyruvate, lactate, and citrate, is critically analyzed.
Since loads are transferred to FRP through its bond with the concrete substrate, its integrity in aggressive outdoor environments is critically important.
Kerner et al. showed that protein abundance is critically different between chaperonin substrate classes (e.g., see Figure 4B in [ 20]).
ECM changes have the potential to influence breast tumor growth within the brain, since the invasion process is critically dependent upon the extracellular substrate [ 25].
This is critically important given the high number of substrates and downstream signaling cascades.
In turn, function of the Na+,K+-ATPase is critically dependent upon the presence of oxygen and a metabolic substrate, generally glucose.
Socialization is critically important.
The matter is critically urgent".
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