Since USPs represent a large and diverse subset of proteins with DUB activity, much of the research has focused on assessing their function, substrates and role in specific diseases.
Overall, the variation in the residues at the hinge regions of HIV-1 protease in the functional modes is required for the protease to process different substrates, which results in specific cleavage rates for the proper functioning of the virus life cycle.
The goal of this work is to deposit nanoscale metal features on a nonconductive substrate in a specific and controlled manner in order to make nanoscale devices.
Similarly, levodione reductase also utilizes the electrostatic interaction between a positively charged surface of the substrate and a Glu residue to bind the substrate in the specific orientation (Sogabe et al. 2003).
Luciferase (i.e., enzyme) emits light by oxidizing luciferin (i.e., substrate) in a specific manner.
In this reaction, BoNT/A cleaves the peptide substrate in a specific location, resulting in peptide cleavage products at 1197.7 and 1699.9 m/z.
Each BoNT cleaves its peptide substrate in a specific location, and that location is different for each of the BoNT serotypes [2], [7], [9], [12].
These interactions are illustrated for DDX19 in Figure 4A: While the variable loop clamps the RNA substrate in a specific conformation, motifs Ia and Ib each coordinate an RNA-backbone phosphate and induce a tilt of one or more RNA bases.
The 3,5-dibromo-2,4-dihydroxycinnamic 3,5-dibromo-2,4-dihydroxycinnamic 3,5-dibromo-2,4-dihydroxycinnamic 3,5-dibromo-2,4-dihydroxycinnamicecagingregroupwashin the cell.
Pin1 catalyzes cis/trans isomerization of proline bonds preceded by phosphorylated serine or threonine residues (pSer/Thr-Pro), thereby altering structure and functions of its substrates in response to specific cues.
