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Electrospun nano-fiber substrates have many favorable properties, such as high surface area-to-volume ratio, nano-topographical features, and polymer concentration (James et al. 2008; Kumbar et al. 2008).
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Buckling of stiff thin films on compliant substrates has many important applications ranging from stretchable electronics to precision metrology and sensors.
Unlike the smooth surface of the conventional Ni foam, the hydrogen templated porous Ni/Cu substrate had many microchannels and voids, which facilitated the adhesion of the deposited Co(OH 2 and improved the cycling performance.
These chaperones are characterized by a promiscuous substrate binding and have many substrates in common (Gong et al. 2009).
Materials with a specific layered structure such as film substrates and multilayer systems have many fascinating features.
What it ultimately means is that X does not have many substrates.
Yeast and human nuclear RNase P are proposed to have many substrates in addition to tRNA precursors [45,48].
The nonspecific recognition of phosphorylated epitopes may prove to be a common issue for antibodies raised to regulatory and target sites of protein kinases that have many substrates.
It is quite possible that laforin may have many substrates (such as other phosphatases), particularly since it is a dual specificity phosphatase that can hydrolyze phosphotyrosine as well as phosphoserine/threonine substrates in vitro (reviewed in 16).
PKMTs are likely to have many additional substrates in addition to histones, but relatively few nonhistone substrates have been characterized, and the substrate specificity for many PKMTs has yet to be defined.
Since the potency of competitive inhibitors is reduced as the concentration of substrate rises, allosteric noncompetitive or uncompetitive inhibitors that bind in the presence of substrates and maintain their efficacy have many advantages.
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