Aromatic acids as benzoic, phenyl acetic and cinnamic acids were not suitable substrates for this lipase for the esterification reaction.
In some fungi (Fomes marginatus, Lentinus lepideus, Piptoporus betulinus) tyrosinase is only present under special cultural conditions, but it can be induced by several chemicals, which are not substrates for this enzyme.
Some DBQs are excellent substrates for this enzyme and are extremely cytotoxic toward human tumor cells both in vitro and in vivo.
This screen identified several substrates with kcat/KM values that are substantially improved over the previously reported fluorogenic substrates for this enzyme.
In contrast, incubation of the CA DADLE analogs with hCYP3A4 showed that these amino-acid-modified analogs are not substrates for this CYP450 isozyme.
To explore the optimal substrates for this application, eight N-acyl derivatives of d-mannosamine were prepared, and their accessibility to NeuNAc aldolase was quantitatively investigated.
Along the last 30 years, a variety of mono- and di-substituted arenes have been studied as substrates for this enzyme, and some interesting observations have been reported regarding the yield and selectivity of the biotransformation.
The results may provide deeper insight into transition-metal catalyzed CN bond formation reactions, as well as help synthetic chemists better design/select the catalyst ligands and the reactant substrates for this type of reaction.
Intriguingly, there are no shared structural features among the identified substrates for this new enzyme.
The identification of several different substrates for this kinase is beginning to explain the wide array of different physiologic abnormalities that occur when this gene product is dysfunctional.
The reported heavy metal substrates for this system include Cu2+, Ag+, Cd2+ and Zn2+ (Fagan and Saier 1994).
