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The separated diastereomers of INX-08189 were shown to have similar activity in the replicon assay and were also shown to be similar substrates for enzyme processing.
Casein glycomacropeptide (cGMP) and lactose, which are purified (or semi-purified) components obtained from side streams from dairy industry operations, were used as substrates for enzyme catalyzed production of 3′-sialyllactose, a model case compound for human milk oligosaccharides (HMOs).
Rice straw (RS) and sugarcane bagasse (BG) biomasses were used as microbial growth substrates for enzyme production.
In this study, zinc oxide (ZnO) nanocrystals with different morphologies were synthesized and used as substrates for enzyme immobilization.
Gram-negative bacteria were permeabilized by chloroform and their peptidoglycans were used as substrates for enzyme digestion as previously described (Briers et al. 2007a).
Nanoscaled materials, such as metal [7] and metal oxide nanospheres [8], carbon nanotubes [9, 10], graphene oxide nanosheets [11], have also been utilized as the substrates for enzyme immobilization.
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Membrane lipids function as enzyme co-factors, establish organelle identity and as substrates for enzymes such as lipases and lipoxygenases.
Nonetheless, secondary metabolites found in plants have the potential to alter the first-pass effect since some of them can mimic substrates for enzymes and transport proteins.
The widely used pesticides fenarimol, vinclozolin, and acephate have been assessed as individual substances, which showed that all three substances are substrates for enzymes of the cytochrome P450 enzyme family (CYP) and induce CYP in the same way.
In this way, FGROUPs can provide a number of possible substrates for enzymes described in generic expressions.
We anticipate that large and structurally diverse libraries of substrates can be used to identify specific substrates for enzymes that have low abundance or reduced catalytic efficiency.
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