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The motivations for the 3D noble metallic nanostructural substrates are to create large-surface area and high-surface dense hot-spots to contribute to SERS with a large enhancement factor, to improve enhancement reproducibility, and to resolve the problem of adhesion layer.
Interactions of protein kinases (PKs) with their substrates are to a large extent determined by residues surrounding the phosphorylation sites and the pattern of residues is named as a phosphorylation motif [ 31, 32].
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How GSMs affect the processing of the substrates is to a large extent unclear.
Identification of the specific substrate that is cleaved by a protease is necessary if the functions of both the protease and its substrate are to be understood.
The control lacking the substrate was to ensure the dependency of the reaction on l-Asn.
The most evident strategy to reduce the effect of toxic substrate is to use less substrate in bioreductions.
Methyltransferase (MT) reactions, in which methyl groups are attached to substrates, are fundamental to many aspects of cell biology and human physiology.
In this mechanism, substrates are permitted to rebind to p38 after getting phosphorylated.
Also, similar to the vertebrates, both endogenous and exogenous substrates are subject to glucosidation in insects.
Graphite substrates are found to be by far the least invasive, making it possible to access the intrinsic low-energy spectrum of 2D materials via STM/STS33,34.
Properly designed polyyne substrates are shown to undergo efficient cascades of thermal cycloaddition reactions initiated by (rate-limiting) benzyne formation.
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