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From the crystal structure it was predicted that flap substrates are processed by recognizing first a nick before processing, however the forked substrates are absent of a nick suggesting processing short flaps by tracking [ 8].
We show that non-amyloid substrates are processed by β-secretase in an endocytosis-independent manner.
Depending on the number of carbon atoms, fatty acid substrates are processed via the beta-oxidation pathway into either acetyl-CoA or propionyl-CoA, the precursors of P3HB and PHBV.
Indeed, vertebrate pri-miRNAs, which are essentially stem-loop structures similar to Rnt1p substrates, are processed by paralogues of RNase III, to mature into effective guides for RNA degradation and translation repression[34].
Autophagy is a cellular degradation process by which cytoplasmic substrates are processed for lysosomal degradation.
The ɛ-cleavage in the APP substrate is analogous to the Notch S3 cleavage site (Sastre et al, 2001; Weidemann et al, 2002) and most likely other γ-secretase substrates are processed in similar ways.
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The substrates were processed with three cycles, 5 min each, in ultrasound bath, followed by 4 h oxygen exposition.
High-quality, translucent, free-standing diamond substrates were processed in a 5 kW microwave plasma chemical vapor deposition (CVD) system using CH4 as precursor.
The diamond coated WC Co substrates were processed at high pressure (7.7 GPa) and high temperature (1000 °C) and their mechanical behavior was investigated by hardness instrumented testing before and after the high-pressure/high-temperature (HPHT) processing.
To investigate the effects of post-processing treatment on both optical and electrical effects, additional samples of ITO films on sodalime glass (SLG) substrates were processed using a different instrument [33] to obtain a pair of film samples with varying thicknesses from 10 to 50 nm in steps of 10 nm.
All invertebrates and substrates were processed within 24 h after sampling.
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