Sentence examples for substrates and lack from inspiring English sources

Although EC functional assays can recapitulate one or more aspects of angiogenesis in vitro, they are often limited by undefined substrates and lack of dependence on key angiogenic signaling axes.

These changes involve alterations in the binding of the enzyme to substrates and lack of binding to arachidonic acid (competitive inhibitor), as well as alterations in the affinity of the flavin coenzyme for electrons.

Oxidative stress, accumulation of substrates, and lack of nutrients and growth factors are all conditions determining a compensatory and cytoprotective activation of CMA through an increase of lamp2A levels on lysosomal membrane [ 5].

An extremely high C/N ratio makes the composting process very slow as there is an excess of degradable substrate and lack of N for the microorganisms.

Compared with the well-refined catalytic systems for asymmetric hydroxymethylation in aqueous media, contemporary catalysts for reactions between hydrophobic substrates have the fault of substrate specificity and lack broader catalytic activities.

This configuration would appear to disfavor hydrolysis of substrates that extend from the inside to the outside of the protease, a feature that likely accounts for IDE's inability to process larger protein substrates and its lack of exopeptidase activity.

In summary, imino NMR data obtained with shiftable versus preshifted substrates provide structural validation for helix shifting upon complex formation with the shiftable SLI substrates and the lack of such phenomenon with preshifted SLI substrates.

Membrane bound PQQGDH has high glucose selectivity but requires suitable detergents for solubilization and purification [ 23], while soluble PQQGDH exhibits a low substrate specificity and lacks thermal stability [ 24, 25].

The N-poor substrate and the lack of a soil seed bank were no obstacles to the establishment of a woody vegetation cover in a relatively short time.

The analysis of AID activity on a series of modified substrates has suggested that one of the causes of the lower activity of AID on 5 mC (relative to non-methylated substrate) and the lack of the activity on 5 hmC is a size restriction against the 5-substituted C imposed by the enzyme's catalytic pocket37, 39.

The fact that WT mice do not show a reduction in brain substrate and the lack of any obvious toxicity, suggests that genistein at these doses in the brain only weakly inhibits tyrosine kinases and this is borne out by chronic studies in the rat and dog suggesting low oral toxicity [8], [9].