Sentence examples for substrates affected by from inspiring English sources

However, deacetylases also have many non-histone protein substrates, such as DNA-binding proteins, transcription factors, signal-transduction molecules, DNA-repair proteins, and chaperone proteins36, 37. A previous study used quantitative MS to identify the acetyl substrates affected by 19 different lysine deacetylase inhibitors38.

In order to spatially-resolve the neuronal substrates affected by selective OX1R or OX2R antagonism in the rat brain, we mapped the modulatory effect of GSK1059865 and JNJ10397049 in animals challenged with d-amphetamine, a drug that stimulates orexigenic activity, using phMRI.

Given the large number of biological substrates affected by sirtuins, the identification of precise and disease-relevant molecular targets is a challenging goal.

This is especially true in light of the results showing that not only are LSD1 substrates affected by HCI2509, H3K27me3 was elevated in both cell lines, suggesting LSD1 inhibition exhibited downstream epignomic regulatory effects.

Using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) technology, we set out to investigate the neural substrates affected by acupuncture at a point (LI-2), an acupoint used in clinical practice [ 13, 15- 17] to treat xerostomia by stimulating saliva production.

Although these mutants are outside of the RING finger or the linker region of c-CBL, their downstream effects are significant so as to cause increased proliferation and migration, but the substrate affected by these mutations are not known yet.

However, the wide distribution of the two ERs and of aromatase, in parallel with the observation that testosterone acts at multiple levels in the brain to control behavior strongly suggests that other brains sites must be implicated and the precise localization of neural substrate affected by steroids deserve additional study.

From this result, it was considered that the crystallite size of the 0.2-μm-thick0.2-μm-thick0.2-μm-thick and SUS substrates was affected by the hardness of the substrates.

Earlier studies have suggested that primarily suboptimal substrates are affected by NatA or NatB knockdown, leaving the most preferred substrates unaffected in their Nt-acetylation states (1, 56).

The hydrolysis of amide substrates is affected by both their P1 and the P1′ part.

On the other hand, pyruvate+malate and palmitoylcarnitine first need to be oxidized through beta-oxidation and/or the TCA cycle, so the H2O2 produced using these substrates is affected by the capacity of these upstream pathways to provide reducing equivalents to the ETC.