Sentence examples for substrates access to from inspiring English sources
Similar reciprocal shifts may underlie the mechanisms of other inhibitors and of the "lateral gate" through which substrates access to the catalytic site.
Activation of lipase involves the opening of the lid on the oil water interface, hence allowing substrates access to the active site [ 37].
Extension of this loop can render UCH-L3 capable of hydrolysing Ub K48- and K63-linked dimers, supporting a restrictive role of the loop in allowing structured substrates access to the active site [ 36].
Before assay, all sample homogenates of whole aortic tissue were subjected to 3 freeze-thaw cycles to disrupt the mitochondrial membranes and allow substrates access to the active sites of the enzymes.
They further showed that increased intestinal translocation of microbial products into the portal vein of colitis-affected mice occurred, which suggests that disruption of the intestinal barrier allowed proinflammatory substrates access to the liver.
In essence the electrode may impede substrate access to the active site of the enzyme.
These changes block substrate access to the catalytic pocket and inhibit the enzyme.
Instead of blocking substrate access to a pre-formed active site, the prosegment enforces a conformation in which proplasmepsin cannot form a functional active site.
The present work describes the fabrication of synthetic microparticles with a similar functionality and the possibility to control substrate access to an enzyme remotely by the application of radiofrequency (RF) signals.
Either substantial, ∼10 15%, transient melting of the protein or rearrangements of hydrogen bonding and solvent interactions of a number of water molecules or both appear to take place to permit substrate access to the protein binding site.
These interactions also lead to decreased PLA2 activity by partially blocking substrate access to the catalytic dyad and by masking several interfacial binding surface residues important for PLA2 interaction with phospholipids.
