Sentence examples for substrate reduction from inspiring English sources

Here, we evaluated the relative merits of substrate reduction therapy (by inhibiting glycogen synthesis) as a potential adjuvant strategy.

This orally active iminosugar inhibits the biosynthesis of glucosylceramides, which accumulate pathologically in macrophages of patients with Gaucher disease (substrate reduction therapy, SRT).

Differences between P. falciparum and human TrxR and details on substrate reduction and inhibitor binding provide the first solid basis for structure-based drug development and lead optimization.

To help designing stirred bioreactors, the substrate reduction to be achieved in a given time interval was empirically related to cBd and YP/B.

Treatment was without any overt toxicity, supporting the notion that substrate reduction by GS-PPMO-mediated inhibition of muscle specific glycogen synthase represents a viable therapeutic strategy for Pompe disease after further development.

A complex metallo-organic species called FeMo-cofactor provides the site of substrate reduction within the MoFe protein, but exactly where and how substrates interact with FeMo-cofactor remains unknown.

Approved therapies were enzyme replacement (N = 10), substrate reduction (N = 1), and small molecules (N = 3).

Possible therapeutic options include enzyme therapy and substrate reduction therapy [66].

Development of effective treatment for glycogen storage diseases types I, II, III and IV using gene therapy, enzyme replacement therapy and substrate reduction therapy approaches.

This can be caused by compaction of the substrate, reduction in porosity of the solid matrix and consequent interference with oxygen transfer.

Currently treatment for Gaucher disease includes enzyme replacement therapy (ERT) and substrate reduction therapy (SRT).