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Long-term potentiation, one of the prime candidates for mediating learning and memory, is widely believed to be a cellular substrate of memory process.
As will be described below, Bob and colleagues came to use remapping as a tool to explore the neural substrate of memory.
This work also suggests that iron-generated reactive species oxygen (ROS) could be a new class of molecules that act as second messengers in signaling cascades related to synaptic plasticity (SP), the putative cellular substrate of memory.
We further interrogated whether differences in excitatory and inhibitory synapses described above could underlie changes in synaptic strength, such as LTP responses, considered the cellular substrate of memory function [ 53].
Similar(56)
However, the neurophysiological substrates of memory deficits occurring in the absence of Arc/Arg3.1 are unknown.
What are the implications of these methodological choices for understanding the component processes and underlying neural substrates of memory retrieval?
It has been demonstrated that aging differentially affects the brain substrates of memory, with the PFC being the most vulnerable, the hippocampus being moderately vulnerable, and the entorhinal cortex being relatively spared [ 12– 12].
These findings are discussed with regard to the neural substrate of episodic memory and psychological models of long-term memory.
Recurrent networks of cortico-cortical connections have been implicated as the substrate of working memory persistent activity, and patterned sequenced representation as needed in cognitive function.
Historically, the primary auditory cortex has been largely ignored as a substrate of auditory memory, perhaps because studies of associative learning could not reveal the plasticity of receptive fields (RFs).
Cells with apparent bistable activity with high firing rates above baseline, while apparently rare in the cortex [5], may still be a fundamental neuronal substrate of working memory.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com