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This work is focused on the evolutionary dynamics of structural disorder and order in homologous sites and shows that in addition to the previously identified mechanism of adding long disordered segments as a mean to alter disorder content during protein evolution (Nido et al. 2012), both direct and indirect amino acid substitutions offer another mechanism for altering disorder content.
However, the whole sequences dN/dS < 1 suggested that the inhibitors were under strong purifying selection pressure (indicating that there might be a structural requirement) and that amino acids at the C-terminal were positively selected; in other words, amino acid-altering substitutions offer fitness advantages that would result in the diversity of WMAI.
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The combination of a CO2 specific anion and bulky group substitution offered higher CO2 permeability as well as appreciable permselectivity than their structural analogue that was devoid of IL functionality.
The space-for-time substitution offers weaker inferences especially for genetic change.
Although such role substitution offers a way to cope with staff shortages, many studies have suggested that it may adversely affect patient-related outcomes (e.g., decreased satisfaction, decreased care quality) and nurse-related outcomes (e.g., increased on-call work, increased sick leave and overtime work, increased workload for registered nurses) [ 142- 144].
These second-chromosome substitution strains offer two major advantages.
In the salary-substitution scheme offered by MDM Bank, a company would take a loan from the bank and redeposit the cash from the loan in the bank.
It does not offer substitutions.
Current crop substitution programs here offer farmers an income of only about 20percentt of their earnings from poppies, said Colonel Dibrell, the American attaché.
Recruitment of qualified GPs from overseas and nurse substitution appear to offer the best prospects for boosting the supply of general practice services to meet demand.
Alloplasmic lines, alien cytoplasm substitution [ 3], offer a unique opportunity to study the nuclear-cytoplasmic interactions and the traits whose expression is dependent on the coordinate activity of nuclear and cytoplasmic genes [ 4- 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com