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To understand the genetic differences between the oseltamivir-resistant and sensitive viruses, amino acid substitutions of representative viruses in the same HA clade were compared.
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In order to identify lineage-specific amino acid substitutions, MCPH1 orthologs of representative primate and other mammalian species were obtained from the NCBI, EMBL and UniProt databases.
Nonetheless Glaucocystis displays the fewest unique substitutions of any monotypic representative of an ancient eukaryotic lineage.
The methods of analysis applied to the c7G substitution are representative of the approaches used to characterize the other modifications discussed in this Account.
The levels of ETVr observed in cell culture and in vitro enzymatic assays of representative clones with ETVr substitutions are shown in Table 1.
First, we compared amino acid substitutions per site within and between influenza virus lineages from 2002 to 2012 and mapped these onto structural models of representative influenza B virus strains.
It has been shown that this substitution may be accomplished by equating the molecular potential energy of a nano-structured material with the strain energy of representative truss and continuum models.
Courtesy of Representative Daniel Lipinski.
Indeed, substitution of a key glutamate residue (E253) in the ligand binding pocket of the C-terminal binding domain of the multidrug transcription regulator, BmrR, resulted in the abolition of binding to the majority of representative cationic co-activators (11).
For example, according to Salanié (2000), the vote is effective when the marginal rate of substitution for the representative agent is equal to the average of the marginal rates of substitution for all agents, which is the case when we have perfect economic equality.
Substitutions of retrograde technology are frowned on.
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