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In Steiner's view, Schrödinger's reasoning relies upon manipulations and substitutions based on purely mathematical analogies.
Sequencing analysis confirmed 4 restriction sites (nucleotide positions 52, 67, 796, and 1369), and a genetic variant was verified at a nucleotide position 641 (C/T substitutions) based on sequences (AF281256).
Since MtbPRPPase shows a strong cooperativity for ATP binding, we cannot quantify the impact of these substitutions based on our predicted structure.
We used these data to infer a functional effect of the observed amino-acid substitutions based on the extent of their conservation.
SIFT predicts the effect of amino acid substitutions based on the assumption that the important amino acid will be conserved in the protein family[ 46].
Although a bias in substitution rate was not found, the difference in substitutions based on proximity to the transcription start site could be related to the asymmetry in the number of substitutions seen around LCRs.
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After the DNA alteration, the students checked the type of phenotype change by mutation (here this means only base substitution) based on the "mutation table" (Fig. 3).
These data are consistent with calculations of molar substitution based on the anhydride reagent extinction coefficient and absorbance measurements at 250 nm (see Methods).
▪ Evaluation of emission reductions through material and fuel substitution based on substitution factors, which represent scenarios for wood usage (based on usage scenarios of demand in the German state of North Rhine-Westphalia); assessment of C-sinks in wood products.
This study generated an efficient MP-degrading enzyme, and provides useful information for enhancing the catalytic efficiency of MPHs via conservative residue substitution based on the consensus approach.
Only if σ i is a function of individual covariates Z [as in eq. (7)] does heterogeneity cause bias in the estimation of marginal rates of substitution based on a DCE.
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