Sentence examples for substitution propensity from inspiring English sources

Substitution properties vary from one position to another, with respect to rates [ 19] as well as to the type of substitution propensity [ 20, 21].

A log-odds matrix introduced by Dayhoff et al. [4] is one of the representations of amino acid substitution propensities.

Therefore specific nt substitutions have a propensity to occur during high throughput sequencing and this becomes apparent only in sequences with the highest quality scores.

Given these results, we concluded that the fast nucleotide substitution rate increased the propensity of mitogenomic rearrangements but were not an absolute requirement.

In particular, in bombinins H, antimicrobial peptides from the skin of fire-bellied toads, the d-residue substitution modulates the folding propensity under conditions, which promote self-aggregation [7,8].

We used the secondary structure prediction tool PSIPRED [ 27] to assess the potential effect of proline substitutions on the helical propensity of the hA segment in both N30 hAI/I eGFP and in its wild-type counterpart N30 hA eGFP.

WT SOD1 and SOD1 containing the FALS-linked G93A and G37R substitutions have low propensities to form soluble oligomers under these conditions, whereas SOD1 with the A4V or I112T substitutions shows substantial oligomerization.

Environment-specific substitution tables, which describe the propensities of residues to mutate in a certain protein-structural environment during evolutionary time, have been used to derive a statistical potential energy function used by the method SDM (Topham et al., 1997; Worth et al., 2011).

However, it remains unclear how the charged glutamate substitution of Lys178 increases coiled-coil propensity.

As predicted by the Paircoil2 algorithm, the proline substitution of L189 strongly reduces the propensity for coiled-coil formation.

Our data clearly show that the A30P α-synuclein conformational properties are significantly altered, probably as a result of the strong helix-breaking propensity of the proline substitution.